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Stay in Santa Cruz Region's best hotels!

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Wonderful: 9+ Very Good: 8+ Good: 7+ Pleasant: 6+
Our top picks Lowest Price First Star rating and price Top reviewed

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Chairu Eco Hotel

Hotel in Santa Cruz de la Sierra

Chairu Eco Hotel features a shared lounge, terrace, a restaurant and bar in Santa Cruz de la Sierra. This 4-star hotel offers a concierge service and a tour desk. really modern and clean. the shower was incredible too. the staff are friendly and nice too.

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9
Wonderful
835 reviews
Price from
$50.16
per night

TRYP by Wyndham Santa Cruz

Hotel in Santa Cruz de la Sierra

Located in Santa Cruz de la Sierra, a 19-minute walk from Gabriel Rene Moreno Autonomous University, TRYP by Wyndham Santa Cruz has accommodations with an outdoor swimming pool, free private parking,... Beautiful brand new hotel. Huge rooms, great breakfast ( the lady making omelettes was lovely) nice pool. Spotless

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9
Wonderful
420 reviews
Price from
$67.15
per night

YVY CASA HOTEL

Hotel in Samaipata

Located in Samaipata, 6.1 miles from Samaipata Fort, YVY CASA HOTEL provides accommodations with a garden, free private parking and a terrace. This is simply a fantastic place to stay. The architecture is beautiful, and the rooms spacious, with comfortable beds. It is very quiet and relaxing. Breakfast was excellent and staff very friendly and helpful. The hotel is just a short walk away from the center of Samaipata. There’s a kitchen that you can use to cook.

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9.2
Wonderful
255 reviews
Price from
$42.75
per night

Marriott Santa Cruz de la Sierra Hotel

Hotel in Santa Cruz de la Sierra

Marriott Santa Cruz de la Sierra Hotel has an outdoor swimming pool, fitness center, a shared lounge and terrace in Santa Cruz de la Sierra. the staff was exceptionally well trained, kindly and helpful

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9.1
Wonderful
308 reviews
Price from
$118.40
per night

Cosmopolitano Hotel Boutique

Hotel in Santa Cruz de la Sierra

Offering an outdoor pool, Cosmopolitano Hotel Boutique is located in the historical center of Santa Cruz de la Sierra. Guests can enjoy the on-site bar. The staff, the location, the rooms (3) the breakfast, everything perfect

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9.1
Wonderful
875 reviews
Price from
$84.14
per night

La Vida es Bella

Hotel in Samaipata

Located in Samaipata, 5.6 miles from Samaipata Fort, La Vida es Bella provides accommodations with a garden, free private parking, a shared lounge and a terrace. Beautiful place! Really quiet and relaxing and the staff was so helpful and kind. Can't recommend this place enough and we look forward to come back!

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9.3
Wonderful
117 reviews
Price from
$60
per night

El Pueblito Hotel Boutique

Hotel in Samaipata

Located in Samaipata, 7 miles from Samaipata Fort, El Pueblito Hotel Boutique has accommodations with an outdoor swimming pool, free private parking, a garden and a shared lounge. Very charming property with super friendly staff

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9.5
Exceptional
224 reviews
Price from
$87
per night

Alfonsina Hotel Boutique

Hotel in Santa Cruz de la Sierra

Conveniently located only a 10-minute walk from Ventura Shopping Center, Alfonsina Hotel Boutique. offers accommodations in Santa Cruz de la Sierra. There couldn’t be a better location. Good restaurants, all around.

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9.4
Wonderful
381 reviews
Price from
$94.50
per night

Hostal Juanita

Hotel in Vallegrande

Hostal Juanita is offering accommodations in Vallegrande. This 1-star hotel offers a shared lounge and room service. There's a terrace and guests can use free WiFi and free private parking. Centrally located. Beautifully decorated. Comfortable bed. Hot shower. Good Wi-Fi. Flexible checkout. Delicious breakfast. And very friendly and helpful staff (two sisters).

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9
Wonderful
10 reviews
Price from
$26
per night

Rústico & Hotel Boutique Las Churapas

Hotel in San José de Chiquitos

Rústico & Hotel Boutique Las Churapas features an outdoor swimming pool, garden, a terrace and bar in San José de Chiquitos. The hotel provides both free WiFi and free private parking. Las Churapas is an amazing place. Owners are kind, helpful, professional, and just very relaxing to be around. The property is gorgeous. I would rather spend a week here than at any of the hotels/resorts in Santa Cruz. Basically, Aidee and Johan make their hotel feel like a peaceful retreat. I will definitely be returning!

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9.2
Wonderful
84 reviews
Price from
$38
per night

Hotels with extra health and safety measures

Find hotels in Santa Cruz Region with added hygiene measures plus high cleanliness ratings

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Most-booked hotels in Santa Cruz Region in the past month

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